South Hills School of Business & Technology was founded in 1970 by S. Paul Mazza Jr. (1930-2013) and his wife, Maralyn J. Mazza. In 2001, the Altoona, PA campus was opened when South Hills purchased the former Altoona School of Commerce. It has been granted approval to offer three Associate in Specialized Technology (AST) degree programs: Graphic Arts, Information Technology, and Software Development Programming and two Online/Hybrid Diploma Programs in Medical Assistant and Medical Coding and Billing.

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